🧪Selective Lysophosphatidic Acid Capture from Plasma Using Templated Polymers

Authored by Strongin, Wang and et al. in 2015, Innovative solid phase extraction (SPE) materials were designed to selectively isolate lysophosphatidic acid (LPA) from human plasma. The research details the synthesis and evaluation of molecularly imprinted polymers (MIPs), specifically optimized with urea-containing functional monomers and methacrylic acid, to enhance non-covalent binding to LPA. These tailored polymers offer a faster and simpler alternative to traditional liquid-liquid extraction methods, effectively removing interfering phospholipids like phosphatidylcholine and lysophosphatidylcholine. The study highlights the high recovery and purity of LPA achieved through a tandem SPE protocol using both imprinted and non-imprinted polymers, signifying a notable advancement in LPA sample preparation for clinical and analytical applications. Find the full-article at Templated polymers enable selective capture and release of lysophosphatidic acid in human plasma via optimization of non-covalent binding to functional monomers - Analyst (RSC Publishing)